Sodium Chloride Injection vs Other IV Solutions: When to Use Each?
Are you feeling dehydrated? Is your energy level low? Do you feel dizzy? If yes, then you might be dehydrated. The solution to all of these issues is the administration of sodium chloride injection vs other IV solutions which can restore your electrolyte balance and help you rehydrate.
The use of sodium chloride injection vs other IV solutions in hospitals is extensive
In this article, let us go through sodium chloride injection vs other IV solutions in terms of their usefulness in medical and home settings. In addition, some of the notable brands of IV fluids have also been discussed below:
Sodium Chloride Injection vs Other IV Solutions: Comparison
Despite having comparable physical properties as all of these are liquid and water-white, sodium chloride injection vs other IV solutions differ in their composition, uses, and limitations. The following section presents a comparison of sodium chloride injection vs other IV solutions:
Sodium Chloride Injection, USP
Sodium chloride injection, USP is a single-use product used after proper dilution. It is commonly used in patients to treat dehydration and thus requires a quick shot of electrolytes and water to restore their fluid balance.
These isotonic solutions generate sodium ions and chloride ions once they enter the blood and thus replenish the body. The following table shows some of the important parameters related to sodium chloride injection:
| Parameters | Values |
| Sterility | Sterile |
| Pyrogenicity | Non-pyrogenic |
| Type of Solution | Concentrated |
| Percentage Composition | 23.4% |
| Milliequivalent Concentration | 4 mEq/ml |
| Vehicle or Base | Water for injection |
| Osmolarity | 8 mOsmol/ml |
| pH | 4.5 to 7.0 |
Administration of sodium chloride injection helps regain lost fluids
Sodium Chloride Injection vs Other IV Solutions
When it comes to the comparison of sodium chloride injection vs other IV solutions, it is essential to take into account the tonicity and composition of intravenous solutions. In addition, the pH as well as osmolarity of the solution also facilitate the physician to decide which solution to choose for a patient. The following table shows these parameters for sodium chloride injection vs other IV solutions:
| Types of Intravenous Fluids | Tonicity | Composition | pH | Osmolarity
(mOsmol/ml) |
| Sodium Chloride Injection | Isotonic | Sodium chloride | 4.5 to 7.0 | 8 |
| 0.9% Normal Saline Solution | Isotonic | Sodium chloride | 5.5 | 286 |
| 0.45% Sodium Chloride Solution | Hypotonic | Sodium chloride | 4.5 to 7.0 | 154 |
| 3% Sodium Chloride Solution | Hypertonic | Sodium chloride | 5.8 | 1027 |
| 5% Dextrose in Water (D5W) | Isotonic (Hypotonic after metabolism) | Dextrose | 4.3 | 252 |
| 5% Dextrose in Water (D5W) | Hypotonic | Dextrose | 4.3 | 252 |
| Ringer Lactate Solution | Isotonic | Sodium chloride, potassium chloride, sodium lactate | 6.5 | 273 |
| 5% Dextrose and 0.45% Sodium Chloride | Hypertonic | Sodium chloride, dextrose | 4.3 | 406 |
| 5% Dextrose and Lactated Ringer’s Solution | Hypertonic | Sodium chloride, potassium chloride, sodium lactate, dextrose, | 6.6 | 530 |
Selecting the Right IV Fluids
Despite their vast utilization and safety, each IV fluid is not suitable for every condition. There are certain conditions that require the use of isotonic IV fluids while others require the administration of hypotonic IV fluids. The following section serves as a guideline for selecting the appropriate IV solution based on patient needs as well as different clinical scenarios:
1.     Type of IV Solution
One of the essential things to take note of is the type of solution required for intravenous fluid therapy. This is essential because some solutions are isotonic and have an electrolyte concentration that mimics that of the blood. However, others either have low salt concentration (hypotonic) or high solute content (hypertonic).
2.     Type of Condition
The next thing is to look into the medical condition for which the IV fluid is to be administered. Selecting the right type of solution can alleviate the problem while a wrong choice can aggravate the condition. The following table shows which type of IV fluids among sodium chloride injection vs other IV solutions are suitable for which conditions:
| Types of Intravenous Fluids | Uses | Limitations/Special Considerations |
| Sodium Chloride Injection | Electrolyte replenishment, dehydration, vehicle for nutrients and other medications, hyponatremia, hemodialysis, metabolic alkalosis | Can cause hypernatremia and high blood pressure, fluid overload, use only if necessary during pregnancy |
| 0.9% Normal Saline | Dehydration, vomiting, diarrhea, blood transfusion, fluid resuscitation for hemorrhaging, hyponatremia, hemodialysis, gastrointestinal suctioning losses | Can worsen hypernatremia, chronic kidney disease, congestive heart failure |
| 0.45% Sodium Chloride Solution | Dehydration, and hypernatremia, assist renal function in increasing urine output | Monitor for hypovolemic patients and those with cerebral edema, do not use in liver disease |
| 3% Sodium Chloride Solution | Hypernatremia, cerebral edema | Monitor for hypervolemia, and hypernatremia, and avoid using in heart and kidney failure |
| 5% Dextrose in Water (D5W) Isotonic | Hypernatremia, kidney issues, dehydration and electrolyte imbalances | Should not be administered in fluid resuscitation as it leaves the intravascular space after metabolizing to its hypotonic state |
| 5% Dextrose in Water (D5W) Hypotonic | Promotes solute excretion from kidneys, treats hypernatremia | Monitor for hypovolemia and cerebral edema, avoid use in liver disease, may worsen hypovolemia |
| Ringer Lactate Solution | Fluid resuscitation, trauma, burns, metabolic acidosis | Can cause or worsen metabolic alkalosis, renal failure |
| 5% Dextrose and 0.45% Sodium Chloride | Fluid replacement, hypoglycemia, nutritional deficiencies | Monitor for hypervolemia, and hypernatremia, avoid using in kidney and heart failure |
| 5% Dextrose and Lactated Ringer’s Solution (DSLR) | Fluid replenishment, electrolyte imbalance, hypoglycemia | Monitor for hypervolemia, and hypernatremia, avoid using in kidney and heart failure |
The administration of a solution with the wrong tonicity can have detrimental effects on the body
Sodium Chloride Injection vs Other IV Solutions in Common Medical Conditions
In addition to the above-enlisted uses and considerations, sodium chloride injection vs other IV solutions can also be employed in home settings for the management of common health issues such as dehydration, minor burns, electrolyte deficiencies, as well as traumatic injuries.
Among sodium chloride injection vs other IV solutions, the following are ideal options for treating commonly occurring medical conditions:
Burns
| Use | Avoid |
| 5% Dextrose in water
Lactated Ringer’s solution |
0.45% Sodium chloride solution |
Electrolyte Imbalance
| Use | Avoid |
| Sodium chloride injection
5% Dextrose in water Lactated Ringer’s solution 0.9% Normal saline solution 0.45% Sodium chloride solution |
Hypotonic IV solutions |
Dehydration
| Use | Avoid |
| Sodium chloride injection
5% Dextrose in water Normal saline Lactated Ringer’s solution |
Hypertonic solutions |
Trauma
| Use | Avoid |
| Normal saline
Sodium chloride injection 5% Dextrose in water and 0.9% sodium chloride solution 5% Dextrose in water and 0.9% sodium chloride solution |
5% Dextrose in water
0.45% Sodium chloride solution |
The sodium chloride injection vs other IV solutions administration helps manage acute blood loss
Sodium Chloride Injection vs Other IV Solutions at Health Supply 770: Features and Specifications
Sodium chloride injection vs other IV solutions is employed in healthcare facilities as well as in home settings whenever the management of dehydration, burns, trauma, and mineral definiteness is required.
These injections and solutions of different brands are manufactured and marketed in the US market. Some of these products are available to choose from at the Health Supply 770 and have been detailed below along with their features and purchase links:
Sol-Millenium PFF001 Sol-Care Saline Flush 0.9% USP Sodium Chloride Injection 10mL fill in 12mL Syringe (400/CS)
US$214.88
Product Details
Sol-Millenium PFF001 Sol-Care saline flush is a product prepared by dissolving sodium chloride in sterile water at a percentage concentration of 0.9% according to the standards set by the United States Pharmacopoeia (USP). The normal saline thus formed is sterile and non-pyrogenic.
The product is packed in individualized syringes with a capacity of 10 ml. The plastic used for constructing these syringes is free from natural rubber latex. For sterilization , the prefilled syringes are exposed to gamma radiation to kill all the microbes.
Medline EMZE010001 IV Flush Solution Sodium Chloride, Preservative Free 0.9% Injection Prefilled Syringe 10 mL 600/CS
Product Details
Medline EMZE010001 IV flush solution contains 0.9% sodium chloride solution which comes in a prefilled syringe. Each syringe contains 10 ml of the product which is completely free from any additives, preservatives, as well as natural rubber latex.
1210-BP Nurse Assist Sodium Chloride IV Flush, 10ML, CS400
US$236.88
Product Details
1210-BP Nurse Assist sodium chloride IV flush has similar specifications and features as mentioned above. The product needs to be kept at USP-controlled room temperature to maintain its effectiveness.
B. Braun 513576 IV Flush Solution Sodium Chloride, Preservative Free 0.9% IV Solution Prefilled Syringe 10 mL
US$199.88
Product Details
Braun 513576 IV flush solution contains normal saline. These prefilled syringes have a shelf-life of up to 2 years which makes them easily storable for longer. The color-coded caps of the syringes help the healthcare providers or caregivers to easily identify the product. Being tamper-proof, the syringes maintain their shape and thus keep the product intact.
B. Braun L8000 Replacement Preparation Sodium Chloride Normal Saline, Preservative Free 0.9% IV Solution Flexible Bag 1,000 mL 12 EA/CA
US$529.88
Product Details
Braun L8000 replacement preparation is also based on a 0.9% sodium chloride in sterile water for injection as its vehicle. The product is packed in a flexible plastic bag which has a capacity of up to 1000 ml. Moreover, the bag is also easily attachable to the IV drip set. The solution also does not contain any additives or preservatives.
B. Braun L5101 Dextrose Water 5% IV Solution Flexible Bag 500 mL CS/24
US$377.88
Product Details
Braun L5101 dextrose water 5% IV solution contains dextrose which is a caloric agent and provides energy to the body. Each plastic bag of B. Braun IV D5W contains up to 500 ml of dextrose in water solution. At the above-mentioned price, 24 such bags can be purchased and stored for future use as the product is high in demand in healthcare setups.
B. Braun L7500: Lactated Ringer’s Solution IV 1000 mL CS/12
US$533.33
Product Details
Braun L7500 Ringer’s lactate solution contains multiple electrolytes and thus is a great option for treating electrolyte imbalance. It comes in a capacity of 1000 ml and is packed in a flexible non-leaching plastic bag. Due to its longer shelf-life, these Ringer’s solutions can be stored for longer.
Grifols 729620 IV Injection IV Fluid Sodium Chloride 0.9% 500mL Bag 20 EA/CS
US$579.88
Product Details
Grifols 729620 IV injection solution is sterile and has 0.9% sodium chloride as its electrolyte. These IV solutions are often administered for the management of low blood volume. The container is free from PVC, natural rubber latex, as well as DEHP and comes with a capacity of up to 500 ml.
*Note: The prices mentioned in the article are taken from the Health Supply 770 website. They may vary over time.
Sodium chloride injection vs other IV solutions can cause swelling if too much fluid is administered
The sodium chloride injection vs other IV solutions mentioned in the article, along with many other medical supplies, can be ordered from Health Supply 770, a reliable name when it comes to medical products. They have a 30-day money-back guarantee and provide your products to you in the shortest possible time. Click the link given in the article to check out the wide range of Sodium chloride injections vs other IV solutions.
Bottom Line
The use of intravenous injections and solutions is a common practice in healthcare. In patients who are either unconscious or are unable to ingest food orally, the IV route serves as the only option for medication and nutrient delivery. In this regard, sodium chloride injection vs other IV solutions are available which can either be administered on their own or can be taken as a vehicle.
When a comparison is made between sodium chloride injection vs other IV solutions, it becomes apparent that all of these fluids have their own uses, advantages, as well as limitations. Therefore, the right solution must be chosen for the right medical condition.
As too much water or salt administered into the body can affect our cells and tissues, care must be taken while selecting a solution of correct tonicity. Overall, sodium chloride injection vs other IV solutions are safe and are therefore extensively employed.
For purchasing sodium chloride injection vs other IV solutions, reliable vendors like Health Supply 770 should be approached. They ensure the provision of quality products along with satisfactory services.
PhD Scholar (Pharmaceutics), MPhil (Pharmaceutics), Pharm D, B. Sc.
Uzma Zafar is a dedicated and highly motivated pharmaceutical professional currently pursuing her PhD in Pharmaceutics at the Punjab University College of Pharmacy, University of the Punjab. With a comprehensive academic and research background, Uzma has consistently excelled in her studies, securing first division throughout her educational journey.
Uzma’s passion for the pharmaceutical field is evident from her active engagement during her Doctor of Pharmacy (Pharm.D) program, where she not only mastered industrial techniques and clinical case studies but also delved into marketing strategies and management skills.
